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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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If you see primary hyperparathyroidism in mothers with vitamin-D deficiency osteomalacia: think of tertiary.

The Journal of the Association of Physicians of India·2005
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Endemic chronic fluoride toxicity and dietary calcium deficiency interaction syndromes of metabolic bone disease and deformities in India: year 2000.

Indian journal of pediatrics·2000
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Nutritional and metabolic rickets.

Indian journal of pediatrics·1997
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Osteoporosis--India: emerging message.

The Journal of the Association of Physicians of India·1996
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Metabolic studies in congenital vitamin D deficiency rickets.

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Fluoride metabolism and fluoride content of stones from children with endemic vesical stones.

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Related Experiment Video

Updated: Jul 5, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Nutritional bone disease in Indian population.

S P S Teotia1, M Teotia

  • 1Sri Sathya Sai General Hospital & Institute of Higher Medical Sciences, Bangalore, India. teotia9@yahoo.com

The Indian Journal of Medical Research
|May 24, 2008
PubMed
Summary

Nutritional bone diseases, including vitamin D deficiency rickets and osteomalacia, are a major health issue in India. These conditions, often linked to low calcium and high fluoride intake, cause significant morbidity and mortality.

Area of Science:

  • Public Health
  • Nutritional Science
  • Endocrinology

Background:

  • Bone diseases and deformities due to nutritional and mineral metabolism disorders are a significant national health concern in India.
  • Existing research on nutritional bone disease is limited, necessitating comprehensive data collection and analysis.

Purpose of the Study:

  • To describe and discuss data on nutritional bone disease prevalence and related disorders in India.
  • To identify the common causes and types of bone diseases affecting the Indian population.

Main Methods:

  • A large-scale survey was conducted across 22 Indian states from 1963 to 2005, covering 337.68 million people in 0.39 million villages.
  • Data analysis focused on 4,11,744 identified patients with bone and mineral metabolism disorders.

Related Experiment Videos

Last Updated: Jul 5, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Main Results:

  • Nutritional bone disease affected 52% (2,13,760) of patients, while endemic skeletal fluorosis accounted for 43% (1,77,200).
  • Common causes included Vitamin D deficiency osteomalacia and rickets, dietary calcium deficiency, and fluoride interaction syndromes.
  • Calcium deficiency alone did not cause rickets in children, but severe maternal depletion led to congenital rickets.

Conclusions:

  • Vitamin D deficiency rickets in children and osteomalacia in mothers are the most prevalent bone disorders in rural India.
  • These nutritional deficiencies and fluoride interactions contribute significantly to morbidity, mortality, and economic burden.