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Updated: Jul 5, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonoids and their glycosides, including anthocyanins
Nigel C Veitch1, Renée J Grayer
1Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, UK. n.veitch@kew.org
This review details over 600 new naturally occurring flavonoids, including aglycones and glycosides. It covers their sources, biological activities, and ecological significance, citing 514 references.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Biochemistry
Background:
- Flavonoids are a diverse group of plant secondary metabolites with significant biological activities.
- Natural product research continually identifies new flavonoid structures and their roles in ecosystems.
Purpose of the Study:
- To comprehensively review newly discovered naturally occurring flavonoids.
- To summarize current knowledge on flavonoid sources, identification, biological activity, biosynthesis, synthesis, and ecological significance.
Main Methods:
- Literature review of scientific publications.
- Compilation and synthesis of data on over 600 new flavonoid examples.
- Analysis of cited references for comprehensive coverage.
Main Results:
- Over 600 new examples of naturally occurring flavonoids (aglycones and glycosides) are described.
- The review encompasses various flavonoid subclasses: flavones, flavonols, chalcones, dihydrochalcones, aurones, flavanones, dihydroflavonols, anthocyanidins, and anthocyanins.
- Key aspects covered include source, identification, biological activity, biosynthesis, synthesis, and ecological/chemosystematic significance.
Conclusions:
- This review provides an updated and extensive overview of the rapidly expanding field of natural product flavonoids.
- The findings highlight the chemodiversity and ecological importance of flavonoids in nature.
- The extensive citation of 514 references underscores the depth and breadth of the reviewed literature.
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