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Multimodal Optical Imaging Platform for Studying Cellular Metabolism
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Multisignal chemosensor for Cr(3+) and its application in bioimaging.

Kewei Huang1, Hong Yang, Zhiguo Zhou

  • 1Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai, PR China.

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|May 24, 2008
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A novel rhodamine B-based sensor, FD7, acts as a highly sensitive chemosensor for chromium(III) ions. This sensor shows fluorescence enhancement and can monitor chromium(III) in living cells.

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Area of Science:

  • Analytical Chemistry
  • Chemical Sensing
  • Biomedical Engineering

Background:

  • Chromium(III) is an essential trace element but can be toxic at elevated levels.
  • Developing selective and sensitive methods for chromium(III) detection is crucial for environmental and biological monitoring.

Purpose of the Study:

  • To develop a novel multisignal chemosensor for the sensitive detection of chromium(III) ions.
  • To investigate the sensor's performance in complex biological environments, including living cells.

Main Methods:

  • Synthesis of a rhodamine B derivative with a ferrocene substituent (FD7).
  • Spectroscopic (fluorescence and absorption) and electrochemical characterization of FD7.
  • Confocal laser scanning microscopy for cellular imaging.

Main Results:

  • FD7 exhibited a prominent fluorescence enhancement in the presence of chromium(III).
  • Significant changes in absorption spectra and electrochemical parameters were observed upon binding with chromium(III).
  • FD7 was successfully employed as a fluorescent probe for monitoring chromium(III) in living cells.

Conclusions:

  • The developed FD7 sensor demonstrates high sensitivity and selectivity for chromium(III) detection.
  • FD7 is a promising tool for real-time monitoring of chromium(III) in biological systems.
  • Multisignal sensing capabilities enhance the reliability of chromium(III) detection.