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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Related Experiment Video

Updated: Jul 5, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Improving medication adherence with a targeted, technology-driven disease management intervention.

David B Lawrence1, Wanda Allison, Joyce C Chen

  • 1Pfizer, Inc., Charleston, South Carolina, USA.

Disease Management : DM
|May 24, 2008
PubMed
Summary

A telephonic intervention improved medication adherence in patients with cardiovascular disease and diabetes. The program significantly increased medication reinitiation rates and reduced the time patients took to restart therapy after nonadherence.

Related Experiment Videos

Last Updated: Jul 5, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Health Services Research
  • Behavioral Science
  • Chronic Disease Management

Background:

  • Treatment adherence is crucial for managing chronic diseases like cardiovascular disease and diabetes.
  • Achieving consistent medication adherence remains a significant challenge in patient care.

Purpose of the Study:

  • To assess the effectiveness of a telephonic intervention in improving medication reinitiation among patients with cardiovascular disease and/or diabetes.
  • To evaluate the rate and timing of medication reinitiation following a period of nonadherence.

Main Methods:

  • BlueCross BlueShield of South Carolina (BCBSSC) used pharmacy claims data to identify patients overdue for medication refills.
  • Care managers received specialized training in behavioral change techniques and patient support.
  • An intervention group received telephonic outreach, while a matched comparison group did not.

Main Results:

  • The intervention group showed a significantly higher medication reinitiation rate (59.3%) compared to the control group (42.1%).
  • Medication reinitiation occurred significantly faster in the intervention group (59.5 days) versus the control group (107.4 days).

Conclusions:

  • A targeted, telephonic disease management intervention effectively promotes patient behavior change.
  • This approach successfully increased medication adherence and reduced the duration of nonadherence in chronic disease patients.