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Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
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Osmophobia in juvenile primary headaches.

E Corletto1, L Dal Zotto, A Resos

  • 1Department of Paediatrics, Juvenile Headache Centre, Paediatric Neurology and Psychiatry Unit, University of Padua Medical School, Padua, Italy.

Cephalalgia : an International Journal of Headache
|May 24, 2008
PubMed
Summary

Osmophobia, a sensitivity to odors, is present in 18.5% of juvenile headache sufferers. This symptom is highly specific for diagnosing migraine without aura in children.

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Area of Science:

  • Neurology
  • Pediatrics
  • Clinical Diagnosis

Background:

  • Headache disorders are common in children and adolescents.
  • Differentiating between migraine without aura and tension-type headache is crucial for effective management.
  • The role of sensory sensitivities, such as osmophobia, in pediatric headache diagnosis requires further investigation.

Purpose of the Study:

  • To determine the prevalence of osmophobia in young patients experiencing headaches.
  • To assess the diagnostic value of osmophobia in distinguishing migraine without aura from episodic tension-type headache in children.

Main Methods:

  • A cohort of 305 consecutive patients at a Paediatric Headache Centre was assessed.
  • A semistructured questionnaire was administered to 275 patients diagnosed with migraine or tension-type headache.
  • Data on osmophobia, phonophobia, and photophobia during headache attacks were collected and analyzed.

Main Results:

  • Osmophobia was reported by 18.5% of juvenile headache sufferers, significantly higher in migraine patients (25.1%) than in tension-type headache patients (8.3%).
  • Osmophobia demonstrated higher specificity than phonophobia or photophobia in differentiating between migraine and tension-type headache.
  • Osmophobia exhibited poor sensitivity (27.1%) but high specificity (92%) in this pediatric cohort.

Conclusions:

  • Osmophobia is a relevant symptom in juvenile headache sufferers, particularly those with migraine.
  • Osmophobia can serve as a valuable supportive diagnostic criterion for distinguishing migraine without aura from tension-type headache in children.
  • Further research into sensory symptoms can enhance the diagnostic accuracy of pediatric headache evaluations.