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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jul 5, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Pathogenesis of asthma.

Stephen T Holgate

    Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
    |May 24, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Asthma is a complex inflammatory airway disease with diverse causes beyond allergies. Understanding structural cell roles and environmental factors reveals new treatment targets for chronic asthma.

    More Related Videos

    Murine Model of Allergen Induced Asthma
    08:05

    Murine Model of Allergen Induced Asthma

    Published on: May 14, 2012

    Related Experiment Videos

    Last Updated: Jul 5, 2026

    Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
    10:39

    Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

    Published on: April 16, 2019

    Murine Model of Allergen Induced Asthma
    08:05

    Murine Model of Allergen Induced Asthma

    Published on: May 14, 2012

    Area of Science:

    • Immunology
    • Pulmonology
    • Cell Biology

    Background:

    • Asthma is traditionally viewed as a T-helper cell type 2 (Th2) mediated inflammatory disorder of the conducting airways.
    • Emerging evidence highlights asthma's heterogeneity, involving diverse immunopathology, clinical phenotypes, and treatment responses.
    • Beyond immune cells, local epithelial, mesenchymal, vascular, and neurologic events contribute to asthma pathogenesis and airway remodeling.

    Purpose of the Study:

    • To explore the multifaceted nature of asthma, moving beyond a purely allergic Th2-dominated model.
    • To investigate the role of structural cells and environmental factors in asthma development and chronicity.
    • To identify novel therapeutic targets by considering additional immunologic and inflammatory pathways.

    Main Methods:

    • Review of current literature on asthma immunopathology and pathogenesis.
    • Analysis of the interplay between immune cells and structural cells in the airway microenvironment.
    • Examination of environmental triggers beyond allergens, including infections, pollution, and diet.

    Main Results:

    • Asthma involves complex interactions between immune and structural cells, contributing to airway inflammation and remodeling.
    • Environmental factors like viral infections, air pollution, and diet play significant roles in asthma exacerbations and persistence.
    • Structural cells act as crucial "soil" for inflammatory "seeds," maintaining chronic asthma phenotypes.

    Conclusions:

    • Asthma is a heterogeneous disease requiring a broader understanding of its underlying mechanisms.
    • Targeting structural cells and non-allergic environmental factors offers promising avenues for new asthma interventions.
    • A comprehensive approach considering diverse inflammatory pathways is essential for effective asthma prevention and treatment.