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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Updated: Jul 5, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Latex allergy: a model for therapy.

J M Rolland1, R E O'Hehir

  • 1Department of Immunology, Monash University, Melbourne, Vic., Australia.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|May 24, 2008
PubMed
Summary
This summary is machine-generated.

Natural rubber latex allergy is a growing concern, especially in developing nations. Research is advancing diagnostics and exploring hypoallergenic vaccines for effective, safe treatment of latex allergy.

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Last Updated: Jul 5, 2026

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08:47

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Published on: March 3, 2023

Area of Science:

  • Immunology
  • Allergology
  • Materials Science

Background:

  • Natural rubber latex allergy emerged significantly with increased latex glove use in the 1980s.
  • High-risk groups include healthcare workers, spina bifida patients, and individuals with fruit/vegetable allergies due to cross-reactivity.
  • Advances in allergen characterization positioned latex allergy as a model for therapeutic development.

Purpose of the Study:

  • To review the evolution, current status, and future therapeutic strategies for natural rubber latex allergy.
  • To highlight the need for improved manufacturing and novel treatments in light of changing global demographics.
  • To explore the potential of immunotherapy and hypoallergenic latex preparations.

Main Methods:

  • Review of epidemiological studies and allergen identification research.
  • Analysis of current and experimental immunotherapy approaches (subcutaneous, sublingual).
  • Investigation into the development of hypoallergenic latex derivatives and vaccine strategies.

Main Results:

  • Allergen identification, epitope mapping, and recombinant allergen production have improved diagnostics.
  • Subcutaneous and sublingual immunotherapies show efficacy but carry high risks of adverse events.
  • Hypoallergenic latex preparations, modified allergen molecules, and T cell epitope peptides are promising therapeutic avenues.

Conclusions:

  • Despite reduced exposure in Western countries, latex allergy remains a global health challenge, necessitating improved manufacturing and novel treatments.
  • Effective, safe immunotherapy and vaccines are crucial for high-risk individuals, with modified allergens and epitope peptides showing potential.
  • Further research into hypoallergenic materials and specific immunotherapy regimens is vital for managing latex allergy.