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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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Published on: May 7, 2019

New choices for patients needing kidney transplantation across antibody barriers

Rob Higgins1, Mark Hathaway, David Lowe

  • 1Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK. robert.higgins@uhcw.nhs.uk

Journal of Renal Care
|May 24, 2008
PubMed

Antibodies in the blood of a kidney transplant recipient can provide a barrier to transplantation, which is additional to the usual possibility of cellular rejection. The antibodies most frequently encountered are ABO (blood group) and human leucocyte antigen (HLA) (tissue-type) antibodies. About 250 living donor transplants each year in the United Kingdom have been stopped because of an antibody barrier. It is now possible to offer a choice of treatment modalities to these people, including exchange transplantation and antibody-incompatible transplantation. It is likely that both schemes will complement each other and both are available in the United Kingdom.

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