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Published on: February 23, 2014
Invasive pneumococcal disease in Singapore children
Chia-Yin Chong1, Thoon Koh-Cheng, Mok Yee-Hui
1KK Women's & Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore. Chong.Chia.Yin@kkh.com.sg
Introduction:
Our retrospective study examined community-acquired invasive pneumococcal disease (IPD) in children admitted to KK Women's and Children's Hospital, Singapore.
Methods:
All pneumococcal isolates from sterile sites from 1997 to 2004 were surveyed.
Results:
There were 147 positive pneumococcal isolates with a mean age of 45 months. The estimated incidence of IPD was 13.6 per 10(5) children under 5 years old. Diagnoses at presentation were: Pneumonia 63.3% (included 14.3% empyema), bacteremia 17%, meningitis 15.6% (included 2.8% meningitis and pneumonia), 4.1% others. The morbidity rate was 25.2%, mortality rate was 6.1%. Antibiotic resistance was: Penicillin 44%, ceftriaxone 15%, erythromycin 62%, trimethoprim-sulfamethoxazole 67%. A separate serotype analysis (n=93, 63%) showed that the current 7valent pneumococcal conjugate vaccine (PCV7) would cover 78.1% of vaccine serotypes and 89% of vaccine-related serotypes for children under 5 years old.
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