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Related Experiment Video

Updated: Jul 5, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

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Published on: February 18, 2016

Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine.

Mariana Bendlin Calzavara¹, Monica Levy Andersen, Daniela Fukue Fukushiro

¹Department of Pharmacology, Universidade Federal de São Paulo, Rua Botucatu, 862, Edifício Leal Prado, CEP 04023-062 São Paulo, SP, Brazil.

Progress in Neuro-Psychopharmacology & Biological Psychiatry

|May 24, 2008

Summary

Sleep rebound, following paradoxical sleep deprivation, reduces amphetamine (AMPH)-induced locomotor effects and behavioral sensitization. This highlights how sleep patterns influence drug-induced behavioral changes.

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Area of Science:

Neuroscience
Pharmacology
Sleep Science

Background:

Paradoxical sleep deprivation (PSD) previously shown to potentiate amphetamine (AMPH)-induced behavioral sensitization.
The conditioned component of AMPH sensitization is increased by PSD.

Purpose of the Study:

To investigate the impact of sleep rebound on AMPH-induced behavioral sensitization.
To determine if sleep recovery influences the acute and context-specific effects of AMPH.

Main Methods:

Induction of sleep rebound via a 24-hour recovery period after PSD.
Administration of AMPH to assess locomotor activity and behavioral sensitization.
Evaluation of context-specific sensitization following sleep rebound.

Main Results:

Sleep rebound significantly attenuated the acute locomotor-stimulating effects of AMPH.
AMPH-induced behavioral sensitization, including its context-specific component, was also reduced by sleep rebound.
These findings indicate a modulatory role of sleep states on drug-induced behavioral plasticity.

Conclusions:

Sleep rebound counteracts the potentiating effects of prior sleep deprivation on AMPH responses.
Sleep conditions play a crucial role in modulating the development and expression of AMPH-induced behavioral sensitization.
Further research into sleep's influence on drug-related behaviors is warranted.