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Related Experiment Video

Updated: Jul 5, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Bidirectional effects on autoimmunity and reproduction.

Ricard Cervera¹, Juan Balasch

¹Department of Autoimmune Diseases, Institut Clínic of Medicine and Dermatology, Faculty of Medicine, University of Barcelona, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Catalonia, Spain. rcervera@clinic.ub.es

Human Reproduction Update

|May 24, 2008

Summary

This summary is machine-generated.

Autoimmunity can impact female fertility, particularly causing recurrent pregnancy loss, especially with antiphospholipid syndrome. Managing reproductive health in women with autoimmune conditions requires integrated care.

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

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Published on: April 11, 2019

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Area of Science:

Reproductive Immunology
Autoimmune Diseases

Background:

Autoimmune diseases disproportionately affect women of reproductive age.
Pregnancy can alter autoimmune disease expression.

Purpose of the Study:

To review the impact of autoimmunity on female fertility, premature ovarian failure (POF), and recurrent pregnancy loss.
To examine the influence of pregnancy in systemic lupus erythematosus (SLE).

Main Methods:

Literature review of PubMed citations.
Selection based on immunological and gynecological relevance.

Main Results:

Antiphospholipid antibodies (aPL) do not correlate with infertility or affect outcomes; treatment is not indicated.
Autoimmunity is a limited cause of POF, mainly linked to autoimmune thyroid diseases.
Autoimmune effects on recurrent spontaneous abortion are debated, but aPL screening is recommended for unexplained cases; SLE pregnancy requires careful management during inactive disease phases.

Conclusions:

Autoimmunity can impair female fertility, with antiphospholipid syndrome linked to recurrent spontaneous abortion.
Multidisciplinary teams are essential for managing reproductive issues in women with autoimmune diseases.