Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Sex Linked Disorders

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

Alterations in Muscle Tone lll

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Sex-linked Disorders

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world experience of abiraterone acetate plus prednisone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: long-term results of the prospective ABItude study.

ESMO open·2022

Same author

SARS-CoV-2 and finding of vein thrombosis: can IMPROVE and IMPROVEDD scores predict COVID-19 outcomes?

European review for medical and pharmacological sciences·2021

Same author

Well-differentiated papillary mesothelioma of the tunica vaginalis: Case report and literature review.

Urology case reports·2018

Same author

Leiomyosarcoma of prostate: Case report and literature review.

Urology case reports·2017

Same author

Erectile dysfunction and alcohol intake.

Urologia·2010

Same author

[Tadalafil versus sildenafil citrate in the treatment of ED:Italian patients' preferences and explanatory notes].

Urologia·2010

Same journal

Trimodal therapy in muscle invasive bladder cancer management.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2020

Same journal

Is androgen deprivation therapy protective against SARS-CoV-2 infection and related complications in prostate cancer patients?

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2020

Same journal

Bowel suture technique for bladder neck reconstruction during RALP and its impact on early continence recovery.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2020

Same journal

Systematic review of neoadjuvant therapy by immune checkpoint inhibitors before radical cystectomy: where do we stand?

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2020

Same journal

Functional and oncological outcomes of 3D clampless sutureless laparoscopic partial nephrectomy for renal tumors with low nephrometry score.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2020

Same journal

Robot-assisted laparoscopic pyeloplasty in children: a systematic review.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2020

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Modeling Multiple Sclerosis in the Two Sexes: MOG_35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Sexual dysfunctions in multiple sclerosis.

G Dachille¹, G M Ludovico, G Pagliarulo

¹Unit of Urology, Hospital San Giacomo Monopoli, Bari, Italy. gdachille@hotmail.com

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology

|May 27, 2008

Summary

This summary is machine-generated.

Sildenafil effectively treated sexual dysfunction in multiple sclerosis patients of both sexes. This neurological condition impacts sexual health, but sildenafil improved erectile function, genital sensitivity, and lubrication, enhancing overall sexual quality of life.

More Related Videos

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Related Experiment Videos

Last Updated: Jul 5, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Modeling Multiple Sclerosis in the Two Sexes: MOG_35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Area of Science:

Neurology
Urology
Sexual Medicine

Background:

Multiple sclerosis (MS) frequently causes sexual dysfunction in patients.
Neurological and central nervous system damage in MS underlies various sexual health issues.
Sexual dysfunction significantly impacts the quality of life for individuals with MS.

Purpose of the Study:

To analyze the prevalence and characteristics of sexual dysfunction in patients with multiple sclerosis.
To evaluate the efficacy and safety of sildenafil in treating sexual dysfunction in both male and female MS patients.
To assess the impact of sildenafil treatment on the sexual quality of life in this patient cohort.

Main Methods:

A cohort of 221 MS patients (97 women, 124 men) aged 20-65 were studied.
52 patients with sexual dysfunction (14 women, 38 men) received sildenafil (50mg, escalating to 100mg).
Efficacy was assessed using the International Index of Erectile Function (IIEF) for men and Index of Female Sexual Arousal (IFSA) for women.

Main Results:

Sildenafil treatment led to significant improvements in erectile function, genital sensitivity, and vaginal lubrication in MS patients.
All analyzed patients reported achievement and maintenance of adequate erection and improved sexual function after sildenafil therapy.
The treatment demonstrated effectiveness in addressing sexual deficiencies related to MS, regardless of patient sex.

Conclusions:

Sildenafil is an effective and safe therapeutic option for managing sexual dysfunction in both men and women with multiple sclerosis.
The study highlights the central nervous system's role in MS-related sexual dysfunctions.
Sildenafil therapy significantly improved the overall sexual quality of life for patients suffering from MS-induced sexual health issues.