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In situ hybridization reveals VIP precursor mRNA-containing neurons in monkey and rat neocortex
D L Benson1, P J Isackson, E G Jones
1Department of Anatomy and Neurobiology, University of California, Irvine 92717.
Brain Research. Molecular Brain Research
|January 1, 1991
Abstract:
The cDNAs encoding monkey vasoactive intestinal polypeptide (VIP) and PHM-27 and rat VIP and PHI-27 were cloned and used to generate antisense RNA probes. Using in situ hybridization, neurons expressing the VIP/PHM or VIP/PHI precursor mRNAs were localized in monkey and rat somatic sensory and visual cortex. In both neocortical areas of both species, labeled cells were observed in all 6 layers as well as the subcortical white matter.