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Related Concept Videos

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: Jul 5, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

Stem cells in colon cancer.

Alexandra Pohl¹, Georg Lurje, Michael Kahn

¹Division of Medical Oncology, University of Southern California, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA.

Clinical Colorectal Cancer

|May 27, 2008

Summary

This summary is machine-generated.

Cancer may originate from rare stem-like cells responsible for tumor growth. This review updates the stem cell model and potential colon cancer treatment targets.

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A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

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Published on: January 22, 2021

Area of Science:

Oncology
Cancer Biology
Stem Cell Research

Background:

The stem cell model proposes that rare cancer cells possess stem-like properties, driving tumor growth.
Self-renewal capacity makes stem cells candidates for malignant transformation.
Recent advancements identify tumor-initiating cells in various solid tumors, including colon cancer.

Purpose of the Study:

To review the biological basis of the cancer stem cell model.
To discuss potential therapeutic targets for colon cancer based on this model.

Main Methods:

Literature review of the cancer stem cell concept.
Analysis of surface markers for identifying tumor-initiating cells.
Synthesis of current research on colon cancer stem cells.

Main Results:

Evidence supports the existence of cancer stem cells in multiple solid tumors.
Specific surface markers aid in identifying these tumor-initiating cells.
The stem cell model offers a framework for understanding tumor heterogeneity and progression.

Conclusions:

The cancer stem cell model is increasingly validated across various cancers.
Targeting cancer stem cells presents a promising therapeutic strategy for colon cancer.
Further research is needed to fully elucidate and exploit cancer stem cell biology for treatment.