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Updated: Jul 5, 2026

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
Published on: April 21, 2016
Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?
1Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, PA, USA. asd30@pitt.edu
Abstract:
Several years ago small molecular weight protein-protein interaction (PPI) antagonists were considered as the Mount Everest in drug discovery and generally regarded as too difficult to be targeted. However, recent industrial and academic research has produced a great number of new antagonists of diverse PPIs. This review structurally analyses small molecular weight PPI antagonists and their particular targets as well as tools to discover such compounds. Besides general discussions there will be a focus on the PPI p53/mdm2.
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