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Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
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Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors
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Canine distemper virus.

Vito Martella1, Gabrielle Elia, Canio Buonavoglia

  • 1Department of Animal Health and Wellbeing, Faculty of Veterinary Medicine, University of Bari, Strada per Casamassima km 3, 70010 Valenzano, Bari, Italy.

The Veterinary Clinics of North America. Small Animal Practice
|May 27, 2008
PubMed
Summary
This summary is machine-generated.

Canine distemper virus (CDV) outbreaks are increasing globally, even in vaccinated dogs. Further surveillance is crucial to monitor new CDV strains and assess vaccine effectiveness against them.

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Area of Science:

  • Veterinary Virology
  • Epidemiology
  • Immunology

Background:

  • Vaccine-based prophylaxis has historically controlled canine distemper.
  • Recent decades show an apparent increase in canine distemper virus (CDV) incidence worldwide.
  • Breakthrough CDV infections in vaccinated dogs are increasingly reported, some with national impact.

Purpose of the Study:

  • To highlight the need for enhanced surveillance of canine distemper virus.
  • To identify emerging CDV variants and understand their epidemiological dynamics.
  • To evaluate the potential impact of new CDV strains on current vaccine efficacy.

Main Methods:

  • Increased epidemiological surveillance for canine distemper virus.
  • Identification and characterization of novel CDV strains.
  • Comparative analysis of vaccine efficacy against prevalent and emerging CDV strains.

Main Results:

  • Global incidence of CDV-related disease appears to be rising.
  • CDV outbreaks are occurring in vaccinated canine populations.
  • New CDV variants may pose a challenge to existing vaccination strategies.

Conclusions:

  • Enhanced CDV surveillance is essential for early detection of variants.
  • Understanding CDV epidemiology is critical for disease control.
  • The efficacy of current vaccines against emerging CDV strains requires thorough evaluation.