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The relation between Helicobacter pylori infection and cardiac syndrome X: a preliminary study

Majid Assadi, Mohsen Saghari, Abdolali Ebrahimi

    International Journal of Cardiology
    |May 27, 2008
    PubMed

    Insights

    Helicobacter pylori infection may be linked to Cardiac Syndrome X, a heart condition. A study found a high prevalence of H. pylori in patients with this syndrome, suggesting a potential role in its development.

    Area of Science:

    • Cardiology
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Cardiac Syndrome X (CSX) is characterized by angina pectoris despite normal coronary angiograms.
    • The underlying causes of CSX remain incompletely understood.
    • Helicobacter pylori (HP) infection is a common gastrointestinal pathogen with potential systemic effects.

    Purpose of the Study:

    • To investigate the association between Helicobacter pylori infection and Cardiac Syndrome X.
    • To explore the potential role of HP infection in the pathogenesis of CSX.

    Main Methods:

    • A study was conducted involving 30 patients with CSX, 30 with stable angina, and 30 healthy controls.
    • The urea breath test (UBT) was used to detect Helicobacter pylori infection in all participants.

    Main Results:

    • A significantly higher prevalence of positive UBT results (indicating HP infection) was observed in CSX patients (50%) compared to the stable angina and healthy control groups (0%).
    • No positive UBT results were found in the stable angina or healthy control groups.

    Conclusions:

    • The findings suggest a potential association between Helicobacter pylori infection and Cardiac Syndrome X.
    • HP infection may play a role in the pathogenesis of CSX, warranting further investigation.
    • Well-designed clinical trials are necessary to confirm these preliminary results and establish causality.

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