Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Adam R Mezo1, Kevin A McDonnell, Alfredo Castro

  • 1Syntonix Pharmaceuticals, Inc., 9 Fourth Avenue, Waltham, MA 02451, USA. amezo@syntnx.com

Bioorganic & Medicinal Chemistry
|May 27, 2008
PubMed

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Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
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Drug-Receptor Interaction: Agonist

Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
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