Related Experiment Video

Updated: Jul 5, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Serum carbohydrate antigen 125 levels in advanced heart failure: relation to B-type natriuretic peptide and left

Dursun Duman1, Fatih Palit, Ergun Simsek

  • 1Haydarpasa Numune Training and Research Hospital, Department of Cardiology, Tibbiye Caddesi, Kadiköy/Istanbul, Turkey. drduman@excite.com

European Journal of Heart Failure
|May 27, 2008
PubMed

Insights

Elevated serum carbohydrate antigen 125 (CA 125) levels in advanced heart failure (AHF) patients correlate with increased left atrial volume (LAVI) and neurohormonal activation, indicating higher disease severity.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Advanced heart failure (AHF) presents complex challenges in patient management.
  • Accurate assessment of left ventricular (LV) filling pressure is crucial for effective AHF treatment.
  • Carbohydrate antigen 125 (CA 125) is a potential biomarker in cardiovascular disease.

Purpose of the Study:

  • To investigate the association between serum CA 125 levels and LV filling pressure parameters in AHF patients.
  • To determine if CA 125 can serve as an indicator of disease severity in AHF.

Main Methods:

  • Studied 49 AHF patients (LV ejection fraction < 0.35, NYHA class III-IV).
  • Assessed left atrial volume indexed to body surface area (LAVI) and mitral inflow E/e ratio using Doppler echocardiography.
  • Measured plasma B-type natriuretic peptide (BNP) levels.

Main Results:

  • Elevated CA 125 (>35 U/ml) found in 57% of patients.
  • Higher CA 125 levels correlated with increased NYHA class, BNP, LAVI, and E/e ratio.
  • Multivariate analysis showed CA 125 significantly associated with BNP and LAVI.

Conclusions:

  • Elevated serum CA 125 is linked to increased LAVI in AHF.
  • CA 125 may reflect heightened neurohormonal activation in advanced heart failure.
  • CA 125 shows potential as a biomarker for assessing AHF severity.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...