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Updated: Jul 5, 2026
06:44
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
Docetaxel-related side effects and their management
Jackie Baker1, Jaffer Ajani, Florian Scotté
1University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. jsbaker@mdanderson.org
Summary
This review highlights limited research on docetaxel side effects, offering evidence-based recommendations for febrile neutropenia management. Further research is needed for other side effects to improve patient care.
Area of Science:
- Oncology
- Pharmacology
- Evidence-based Medicine
Background:
- Docetaxel is a key cancer treatment, but its efficacy is hindered by side effect management challenges.
- Effective management of docetaxel-induced side effects is crucial for optimizing patient outcomes in clinical practice.
Purpose of the Study:
- To review existing literature on docetaxel-related side effects.
- To provide evidence-based recommendations for the prevention and management of these side effects, particularly for oncology nurses.
Main Methods:
- Systematic literature search of PubMed, ASCO, and Cochrane Library databases.
- Focused on English articles from the past 5 and 2 years, respectively.
- Identified six common docetaxel side effects relevant to oncology nursing.
Main Results:
- 103 citations were reviewed; only 14 addressed prevention/management strategies for febrile neutropenia, hypersensitivity reactions, fluid retention, and nail changes.
- No articles were found on asthenia or neuropathy.
- Evidence-based recommendations were formulated for granulocyte-colony stimulating factor (G-CSF) in febrile neutropenia.
Conclusions:
- The current evidence base is insufficient for formulating recommendations on most docetaxel side effects beyond febrile neutropenia.
- Authors' experience suggests most side effects are mild and manageable with supportive care.
- Emphasizes the need for shared experiences and further research to enhance healthcare professionals' ability to provide optimal patient care.
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