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Multiple organ system extracorporeal support in critically ill children

Joseph A Carcillo1

  • 1Pediatric Critical Care, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213, USA. carcilloja@ccm.upmc.edu

Pediatric Clinics of North America
|May 27, 2008
PubMed

Insights

Extracorporeal support aids failing organs in critically ill children. Optimal outcomes require reversible disease, expert care minimizing hemolysis, and goal-directed therapy.

Area of Science:

  • Pediatric Critical Care Medicine
  • Extracorporeal Therapies

Background:

  • Multiple organ system failure (MOSF) is a critical condition in infants and children.
  • Extracorporeal support offers vital organ function replacement.

Purpose of the Study:

  • To provide a framework for implementing multidisciplinary team approaches for extracorporeal support in pediatric MOSF.
  • To highlight key factors for optimizing extracorporeal therapy benefits.

Main Methods:

  • Review of extracorporeal support modalities for pediatric MOSF.
  • Framework development for multidisciplinary team implementation.
  • Emphasis on expert management and goal-directed therapy.

Main Results:

  • Extracorporeal support effectively sustains brain, heart, lung, liver, and kidney function.
  • Support extends to coagulation, red blood cell, and immune cell functions.
  • Successful application depends on reversible underlying disease and expert, monitored therapy.

Conclusions:

  • Extracorporeal support is a significant advancement in pediatric critical care.
  • Expertise, hemolysis prevention, and goal-directed approaches are crucial for optimal outcomes.
  • A multidisciplinary team approach is essential for effective implementation.

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