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Published on: August 30, 2019
HLA class II transgenic mice mimic human inflammatory diseases
Ashutosh K Mangalam1, Govindarajan Rajagopalan, Veena Taneja
1Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Advances in Immunology
|May 27, 2008
Summary
Humanized HLA-class II transgenic mice models are crucial for studying autoimmune diseases. These models help understand the role of human leukocyte antigen (HLA) class II genes in disease development and pathogenesis.
Area of Science:
- Immunology
- Genetics
Background:
- MHC class II genes, particularly HLA-DR and -DQ alleles, are strongly associated with familial clustering of autoimmune diseases.
- In vitro studies have limitations in elucidating the in vivo role of HLA class II genes due to population heterogeneity and genetic complexity.
Purpose of the Study:
- To overcome limitations in studying HLA class II gene function in vivo.
- To develop and utilize humanized HLA-class II transgenic mouse models for autoimmune disease research.
Main Methods:
- Generation of HLA-class II transgenic mice.
- Development of in vivo disease models for common autoimmune and inflammatory diseases.
- Analysis of T-cell repertoire shaping by human class II molecules in transgenic mice.
Main Results:
- Transgenic mice exhibit HLA restriction mirroring human responses.
- These models implicate potential triggering mechanisms and autoantigens in human autoimmune diseases.
- Similar antigenic epitopes observed in human diseases were identified in these mouse models.
Conclusions:
- Humanized HLA-class II transgenic mice are valuable tools for deciphering the immunopathogenesis of inflammatory and autoimmune diseases.
- These models provide critical insights into the role of HLA class II molecules in disease predisposition and development.
