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Penetration and accumulation of moxifloxacin in uterine tissue

Heino Stass1, Dagmar Kubitza, Baybur Aydeniz

  • 1Bayer HealthCare AG, Wuppertal, Germany. heino.stass@bayerhealthcare.com

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|May 27, 2008
PubMed
Abstract

Insights

Moxifloxacin effectively penetrates uterine tissue, reaching concentrations adequate for eradicating common pelvic inflammatory disease (PID) pathogens. This antibiotic demonstrates safety and tolerability for PID treatment.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Gynecology

Background:

  • Pelvic inflammatory disease (PID) is a serious infection.
  • Effective antibiotic penetration into uterine tissue is crucial for PID treatment.
  • Moxifloxacin is a broad-spectrum antibiotic.

Purpose of the Study:

  • To assess moxifloxacin's uterine tissue penetration.
  • To determine if moxifloxacin concentrations are sufficient to treat PID pathogens.

Main Methods:

  • Prospective, multicenter, open-label study.
  • Single 400-mg intravenous dose of moxifloxacin administered.
  • Uterine tissue and plasma concentrations measured at 1, 2, 4, 7, and 24 hours post-infusion.

Main Results:

  • Moxifloxacin achieved significant uterine tissue accumulation.
  • Peak concentrations in plasma and tissue occurred at 1 hour.
  • Tissue-to-plasma ratios ranged from 1.7 to 2.1 over 24 hours.
  • Moxifloxacin was safe and well-tolerated.

Conclusions:

  • Achieved uterine tissue concentrations of moxifloxacin exceed minimum inhibitory concentrations for common PID pathogens.
  • Moxifloxacin is a promising therapeutic option for PID.

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