Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 5, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

Rapid avoidance acquisition in Wistar-Kyoto rats.

R J Servatius1, X Jiao, K D Beck

  • 1Stress & Motivated Behavior Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, United States. Richard.Servatius@va.gov

Behavioural Brain Research
|May 27, 2008
PubMed
Summary

Wistar-Kyoto (WKY) rats exhibit lower activity and stress sensitivity but superior avoidance learning and response persistence compared to Sprague-Dawley (SD) rats. This makes WKY rats a valuable model for studying anxiety disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The complexity of finding fit-for-purpose real-world data for oncology patients with rare <i>NTRK</i> gene fusions and a novel solution.

ESMO real world data and digital oncology·2026
Same author

Neutrophil-lymphocyte ratio and hypersensitive C-reaction protein are associated with miscarriage during the second trimester of pregnancy.

Journal of biological regulators and homeostatic agents·2021
Same author

[Changes of retinal structure after systemic immunosuppressive treatment in eyes with Vogt-Koyanagi-Harada disease].

Zhonghua yi xue za zhi·2020
Same author

The accuracy of bone mineral density measurement using dual-energy spectral CT and quantitative CT: a comparative phantom study.

Clinical radiology·2019
Same author

An Anisotropic Fluid-Solid Model of the Mouse Heart.

Computers in cardiology·2019
Same author

Gradient magnet design for simultaneous detection of electrons and positrons in the intermediate MeV range.

The Review of scientific instruments·2019

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Psychology

Background:

  • Trait stress-sensitivity and avoidance behaviors are crucial in understanding anxiety disorders.
  • Rodent models are essential for dissecting the neurobiological underpinnings of anxiety-related behaviors.

Purpose of the Study:

  • To investigate the relationship between trait stress-sensitivity, avoidance acquisition, and avoidance response perseveration in Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats.
  • To evaluate WKY and SD rats as potential models for anxiety disorders based on their behavioral phenotypes.

Main Methods:

  • Behavioral assessment in an open field test prior to escape/avoidance (E/A) acquisition and extinction.
  • E/A performance was measured using a discrete trial lever-press protocol with signal-shock conditions.

More Related Videos

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Related Experiment Videos

Last Updated: Jul 5, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

  • Analysis of "warm-up" effect, intertrial responses (ITRs), and extinction rates between WKY and SD rat strains.

    • Main Results:

    • WKY rats displayed lower open field activity and stress sensitivity but significantly outperformed SD rats in E/A acquisition.
    • SD rats exhibited a "warm-up" effect, with reduced avoidance on initial trials, unlike WKY rats.
    • WKY rats showed delayed extinction and persistent first-trial avoidance and ITRs, indicating superior response perseveration.

    Conclusions:

    • WKY rats possess a unique combination of behavioral inhibition and robust avoidance learning and perseveration.
    • The WKY rat strain serves as a promising model for investigating the mechanisms underlying anxiety disorders.
    • Differences in avoidance behavior between WKY and SD rats highlight strain-specific contributions to anxiety-related phenotypes.