Prostate tissue androgens: history and current clinical relevance

Area of Science:

• Endocrinology
• Urology
• Oncology

Background:

• Androgen levels in prostate tissue offer unique insights not obtainable from serum levels.
• Dihydrotestosterone (DHT) and testosterone are the primary androgens influencing prostate health.

Purpose of the Study:

• To highlight the significance of direct prostate tissue androgen assays.
• To explore the established and potential applications of these assays in understanding and managing prostate conditions.

Main Methods:

• Assaying dihydrotestosterone (DHT) and testosterone levels in quick-frozen prostate biopsy cores or surgical specimens.

Main Results:

• Established DHT's role in BPH pathogenesis and treatment mechanisms.
• Provided understanding for prostate cancer chemoprevention and castration resistance.
• Offered insights into testosterone replacement therapy safety and racial disparities in prostate cancer.

Conclusions:

• Prostate tissue androgen assays are crucial for understanding BPH and prostate cancer.
• These assays have significant implications for treatment, chemoprevention, and patient management.
• The transition of prostate tissue androgen determination from research to clinical practice is anticipated.