[Microscopic colitis associated with celiac disease probably triggered by the administration of venlafaxine]

Area of Science:

• Gastroenterology
• Clinical Case Reports
• Pharmacology

Background:

• Microscopic colitis and celiac disease are distinct gastrointestinal conditions.
• The co-occurrence of these two conditions is exceptionally rare in clinical practice.
• Understanding rare disease associations is crucial for comprehensive patient care.

Observation:

• A 67-year-old patient presented with symptoms potentially related to both microscopic colitis and celiac disease.
• The patient had recently been administered venlafaxine, a serotonin-norepinephrine reuptake inhibitor.
• This case highlights a potential, albeit uncommon, drug-induced or associated phenomenon.

Findings:

• The case describes the simultaneous presentation of microscopic colitis and celiac disease.
• Venlafaxine administration preceded the observed clinical scenario.
• The study explores potential pathophysiologic mechanisms linking these conditions and the medication.

Implications:

• This case expands the known spectrum of rare gastrointestinal associations.
• It prompts consideration of venlafaxine in the differential diagnosis for patients with unexplained gastrointestinal symptoms and potential celiac disease or microscopic colitis.
• Further research into drug-induced gastrointestinal pathologies is warranted.