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Updated: Jul 5, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
Published on: December 1, 2023
Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis
Judith M Greer1, Michael P Pender
1School of Medicine, The University of Queensland, Brisbane, Qld 4072, Australia. j.greer@uq.edu.au
Abstract:
Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease.
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