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Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...

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Related Experiment Video

Updated: Jul 5, 2026

Ethylene Polymerizations Using Parallel Pressure Reactors and a Kinetic Analysis of Chain Transfer Polymerization
07:28

Ethylene Polymerizations Using Parallel Pressure Reactors and a Kinetic Analysis of Chain Transfer Polymerization

Published on: November 27, 2015

Allosteric models for cooperative polymerization of linear polymers.

Emily R Miraldi1, Peter J Thomas, Laura Romberg

  • 1Department of Mathematics, Oberlin College, Oberlin, Ohio 44074, USA.

Biophysical Journal
|May 27, 2008
PubMed
Summary

A new model explains how single-stranded polymers, like bacterial FtsZ, can assemble cooperatively. This advances our understanding of cytoskeletal dynamics and cellular regulation.

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OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
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Related Experiment Videos

Last Updated: Jul 5, 2026

Ethylene Polymerizations Using Parallel Pressure Reactors and a Kinetic Analysis of Chain Transfer Polymerization
07:28

Ethylene Polymerizations Using Parallel Pressure Reactors and a Kinetic Analysis of Chain Transfer Polymerization

Published on: November 27, 2015

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
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Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization

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OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

Area of Science:

  • Biochemistry
  • Cell Biology
  • Biophysics

Background:

  • Cytoskeletal polymer assembly is crucial for cellular regulation.
  • Traditional models explain cooperative polymerization in multistranded polymers, but not linear ones.
  • Bacterial FtsZ assembly does not fit existing models.

Purpose of the Study:

  • To develop a model for cooperative polymerization of single-stranded polymers.
  • To explain the assembly of bacterial FtsZ (tubulin homolog).
  • To provide a mathematical framework for allosteric assembly systems.

Main Methods:

  • Developed a novel model for cooperative polymerization not requiring multistranded polymers.
  • Derived equations for polymer concentrations, subunit conformations, and end affinities.
  • Analyzed the role of conformational changes in subunit association.

Main Results:

  • The model explains how single-stranded polymers can assemble cooperatively via conformational changes.
  • Low-affinity monomers transition to high-affinity subunits within polymers.
  • Predicted limitations on nucleation due to unstable intermediates in dimer formation.

Conclusions:

  • The new model accurately describes FtsZ assembly and other allosteric systems.
  • Cooperative polymerization can occur in single-stranded polymers through conformational shifts.
  • The framework accommodates systems with and without cooperativity.