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Related Experiment Video

Updated: Jul 5, 2026

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
08:07

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

Clinically relevant cell sources for TMJ disc engineering.

D E Johns1, M E Wong, K A Athanasiou

  • 1Department of Bioengineering, Rice University, Houston, TX 77251, USA.

Journal of Dental Research
|May 27, 2008
PubMed
Summary
This summary is machine-generated.

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Costal chondrocytes show promise for temporomandibular joint (TMJ) disc tissue engineering. These cells, when used in a scaffoldless approach, produced superior extracellular matrix compared to TMJ disc cells and dermal fibroblasts.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Temporomandibular joint (TMJ) disorders affect many patients, with current treatments often limited.
  • Tissue engineering offers a potential solution by regenerating diseased TMJ disc tissue using autologous cells.
  • Developing functional TMJ disc replacements requires identifying optimal cell sources and engineering strategies.

Purpose of the Study:

  • To compare the efficacy of different cell sources for scaffoldless TMJ disc tissue engineering.
  • To evaluate costal chondrocytes, dermal fibroblasts, a mixture of both, and native TMJ disc cells.
  • To determine which cell source yields constructs with the most suitable matrix and mechanical properties for TMJ disc replacement.

Main Methods:

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Last Updated: Jul 5, 2026

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
08:07

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

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  • Scaffoldless tissue engineering constructs were created using costal chondrocytes, dermal fibroblasts, a mixed cell population, and TMJ disc cells.
  • Constructs were analyzed for morphological and biochemical characteristics, including collagen and glycosaminoglycan production.
  • Compressive properties of the engineered tissues were assessed and compared.

    • Main Results:

    • Costal chondrocyte and mixed cell constructs demonstrated superior morphology and biochemistry compared to native TMJ disc and dermal fibroblast constructs.
    • Costal chondrocyte constructs produced significantly higher amounts of collagen (40x) and glycosaminoglycans (800x) than native TMJ disc constructs.
    • The compressive properties of costal chondrocyte and mixture constructs were not significantly different from native TMJ disc constructs.

    Conclusions:

    • Costal chondrocytes are a viable and effective cell source for TMJ disc tissue engineering.
    • Scaffoldless constructs using costal chondrocytes can generate extracellular matrix with potential for TMJ disc replacement.
    • Further research into costal chondrocyte-based TMJ disc regeneration holds significant clinical potential.