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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

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Related Experiment Video

Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Myocardial involvement in systemic sclerosis.

L Belloli1, N Carlo-Stella, G Ciocia

  • 1Rheumatology Unit, IRCCS Humanitas Clinical Institute, University of Milan, Milan, Italy.

Rheumatology (Oxford, England)
|May 27, 2008
PubMed
Summary
This summary is machine-generated.

Myocardial perfusion defects are common in Systemic Sclerosis (SSc). Severe skin, digital ulcers, and esophageal issues may indicate heart involvement, suggesting screening for SSc patients.

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Last Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

Area of Science:

  • Cardiology
  • Rheumatology
  • Nuclear Medicine

Background:

  • Systemic Sclerosis (SSc) can affect various organs, including the heart.
  • Myocardial microvascular dysfunction is a potential complication in SSc patients, even those without overt cardiovascular symptoms.

Purpose of the Study:

  • To determine clinical and laboratory risk factors for myocardial microvascular involvement in SSc patients.
  • To assess the prevalence of myocardial perfusion defects in SSc patients with subclinical cardiovascular disease.

Main Methods:

  • Utilized 99m-Tc sestamibi gated myocardial perfusion SPECT with a stress-rest protocol.
  • Evaluated 21 SSc patients who were clinically silent for cardiovascular disease.
  • Correlated perfusion defects with clinical and laboratory markers.

Main Results:

  • Myocardial perfusion defects were identified in 38% of SSc patients.
  • Defects were significantly associated with high skin scores, digital ulcers, and esophageal involvement.
  • A trend suggested a link with anti-Scl 70 antibody positivity.

Conclusions:

  • Myocardial perfusion defects are frequent in SSc.
  • Severe skin thickness, digital ulcers, and esophageal involvement may necessitate screening for cardiac involvement in SSc patients.
  • Prostanoid therapy showed potential in restoring myocardial perfusion in some patients, warranting further investigation.