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Hemorheological disturbances in cerebrovascular diseases

I Velcheva1, N Antonova, E Titianova

  • 1Department of Neurology, Medical University, Sofia, Bulgaria. ivelcheva@yahoo.com

Clinical Hemorheology and Microcirculation
|May 27, 2008
PubMed

Insights

Hemorheological disturbances, including increased fibrinogen and blood viscosity, are linked to cerebrovascular diseases (CVD) and stroke risk factors. These findings suggest hemorheological variables can predict stroke development and recurrence.

Area of Science:

  • Neuroscience
  • Cardiovascular Medicine
  • Hematology

Background:

  • Cerebrovascular diseases (CVD) pose a significant health burden.
  • Understanding risk factors (RF) for CVD is crucial for prevention and treatment.
  • Hemorheological disturbances may play a role in CVD pathogenesis.

Purpose of the Study:

  • To investigate the relationship between hemorheological disturbances and clinical symptoms in CVD patients.
  • To explore the association of hemorheological variables with established RF for CVD.
  • To determine if hemorheological factors can serve as predictors for stroke development and recurrence.

Main Methods:

  • Study included 68 CVD patients (TIA, UCI) and 47 controls.
  • Collected data on CVD risk factors via questionnaire.
  • Measured hemorheological variables: leucocytes, hemoglobin, hematocrit, fibrinogen, plasma viscosity (PV), and whole blood viscosity (WBV).
  • Calculated hemorheological indices: erythrocyte aggregation (IEA), erythrocyte deformability (IED), and oxygen transport (TO(2)).

Main Results:

  • Arterial hypertension was the most common RF.
  • Significant increases in fibrinogen (TIA), PV, and WBV were observed in CVD patient groups.
  • Hemorheological variables showed significant correlations with blood pressure, age, cholesterol, physical activity, and BMI.
  • Hemorheological parameters were elevated in patients with transient ischemic attacks and chronic unilateral cerebral infarctions.

Conclusions:

  • Hemorheological disturbances are associated with CVD and its clinical manifestations.
  • Blood pressure, age, cholesterol, physical activity, and BMI are correlated with hemorheological changes in CVD.
  • Hemorheological variables are potential risk factors for stroke development and recurrence.

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