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Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4

Jingjing Sun1, Jade Schiffman, Anitha Raghunath

  • 1Department of Genitourinary Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.

Cancer Immunity
|May 28, 2008
PubMed
Summary

Blockade of cytotoxic T lymphocyte antigen-4 (CTLA-4) enhances anti-tumor responses but can cause immune-related adverse events (irAEs). Decreased IL-10 levels after CTLA-4 therapy may explain irAEs in some cancer patients.

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