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Updated: Jul 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin
Ahmad Shaabani1, Ebrahim Soleimani, Ali Hossein Rezayan
1Department of Chemistry, Shahid Beheshti University, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
Abstract:
A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature.
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