Related Experiment Video
Updated: Jul 5, 2026
11:49
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
Published on: March 8, 2019
Occupational methacrylate and acrylate allergy from glues
Kristiina Aalto-Korte1, Kristiina Alanko, Outi Kuuliala
1Finnish Institute of Occupational Health, Control of Hypersensitivity Diseases, FI-00250 Helsinki, Finland. kristiina.aalto-korte@ttl.fi
Contact Dermatitis
|May 28, 2008
Summary
Allergic reactions to acrylic monomers from occupational glue exposure were studied. 2-hydroxyethyl methacrylate (2-HEMA) and ethyleneglycol dimethacrylate (EGDMA) are key indicators for contact allergy to sealants.
Area of Science:
- Occupational dermatology
- Allergen contact dermatitis
- Polymer chemistry
Background:
- Methacrylate and acrylate allergies are frequently caused by glues and sealants.
- Occupational exposure to acrylic monomers in glues is a significant concern.
- Understanding sensitization patterns is crucial for preventing allergic reactions.
Purpose of the Study:
- To analyze patterns of allergic patch test reactions to acrylic monomers.
- To correlate reactions with specific glue exposures in sensitized patients.
- To identify key screening allergens for occupational methacrylate allergy.
Main Methods:
- Screening of patch test files from 1994-2006 at the Finnish Institute of Occupational Health.
- Analysis of clinical records of patients with allergic reactions to the 'Methacrylate series'.
- Inclusion of only patients with occupational exposure to acrylic glues.
Main Results:
- Ten patients showed allergic reactions to acrylic monomers from occupational glue exposure.
- Anaerobic sealants were used by 9 patients; cyanoacrylate and bi-component adhesives by others.
- All patients reacted to 2-hydroxyethyl methacrylate (2-HEMA) and ethyleneglycol dimethacrylate (EGDMA).
Conclusions:
- 2-hydroxyethyl methacrylate (2-HEMA) and ethyleneglycol dimethacrylate (EGDMA) are effective screening allergens.
- These allergens are valuable for diagnosing contact allergy to anaerobic sealants.
- They also identified a case of allergy from bi-component acrylic glue.
Related Concept Videos
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
02:06Allergic Reactions
Overview
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
01:27Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
01:12Local Anesthetics: Adverse Effects
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
00:53Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...