Related Experiment Video
Updated: Jul 5, 2026
08:47
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Relationship between rhinitis duration and worsening of nasal function
Giorgio Ciprandi1, Ignazio Cirillo, Angela Pistorio
1Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
Summary
Persistent allergic rhinitis (PAR) can progressively worsen nasal airflow over time. This study shows reduced nasal airflow in patients with long-term PAR compared to those with short-term PAR.
Area of Science:
- Otolaryngology
- Allergology
- Pulmonology
Background:
- Asthma is linked to airway remodeling, but less is known about this in allergic rhinitis (AR).
- Investigating airway changes in AR patients is crucial for understanding disease progression.
Purpose of the Study:
- To assess nasal airflow in patients with persistent allergic rhinitis (PER).
- To determine if the duration of PER impacts nasal function.
Main Methods:
- Prospective evaluation of 100 patients with PER (50 short-term, 50 long-term).
- Clinical assessment, skin prick testing, and rhinomanometry were used.
- Nasal airflow was measured using rhinomanometry.
Main Results:
- Patients with long-term PER (median duration 9 years) had significantly lower nasal airflow (median 348 mL/sec) than those with short-term PER (median duration 1 year, median 466 mL/sec).
- A statistically significant difference (P < 0.0001) was observed.
Conclusions:
- This study presents initial evidence of declining nasal airflow in PER patients.
- Nasal airflow impairment appears to correlate with the duration of persistent allergic rhinitis.
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