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Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study.

S Trompet1, A J M de Craen, P Slagboom

  • 1Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands. s.trompet@lumc.nl

Experimental Gerontology
|May 28, 2008
PubMed
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The C804A polymorphism in the lymphotoxin-alpha (LTA) gene is linked to an increased risk of vascular events, particularly clinical strokes in men. Further research is needed to confirm these findings on LTA gene variants.

Area of Science:

  • Cardiovascular Genetics
  • Inflammation and Atherosclerosis
  • Molecular Epidemiology

Background:

  • Inflammation is a key driver in atherosclerosis development, a major cause of vascular events.
  • Lymphotoxin-alpha (LTA), a pro-inflammatory cytokine, is present in atherosclerotic lesions.

Purpose of the Study:

  • To examine the association between the LTA gene's C804A polymorphism and coronary/cerebrovascular events.
  • To investigate potential gender-specific effects of this polymorphism on vascular outcomes.

Main Methods:

  • Analysis of 5804 participants from the PROSPER study.
  • Utilized Cox-proportional hazards models adjusted for relevant covariates.
  • Assessed primary (composite vascular events) and secondary (coronary/cerebrovascular components) endpoints.

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Main Results:

  • A significant association was found between the C804A polymorphism and the primary endpoint (p=0.03).
  • This association was primarily observed in males and significantly linked to clinical strokes (p=0.02).

Conclusions:

  • The LTA C804A polymorphism is associated with clinical stroke risk, especially in men.
  • These findings highlight a potential genetic susceptibility factor for stroke in males.
  • Further validation studies are recommended to confirm the role of LTA gene variants in vascular disease.