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[Effect of continuous blood purification for management of multiple organ failure with acute renal failure]
Lu Chen1, Jiu-hong Li, Ying Jiang
1Department of Nephrology, Shenzhen Sixth People's Hospital, Shenzhen 518052, China. fanghc-0397@sohu.com
Objective:
To evaluate the effect of continuous blood purification (CBP) for treatment of multiple organ failure (MOF) with acute renal failure (ARF).
Methods:
Forty-seven patients with MOF underwent CBP for an average of 3.1-/+0.5 days averagely. Continuous veno-venous hemofiltration was performed at daytime, and the substitute fluids were infused with pre-dilution at the rate of 2000-4000 ml/h. The general conditions, clinical symptoms, and serum biochemical indexes of the patients were observed and MODS score was calculated.
Results:
After CBP, the MODS score of the patients decreased significantly from 9.1-/+3.5 to 5.4-/+2.7 (P<0.01) and serum creatinine decreased from 451.3-/+134.5 to 223.7-/+100.2 micromol/L (P<0.05). Twenty-nine patients survived with the survival rate of 61.7%.
Conclusion:
CBP is effective for treatment of MOF and may help reduce the mortality rate of MOF complicated by ARF.
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