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A case with life-threatening interstitial pneumonia associated with bucillamine treatment
Yuiko Ogiwara1, Hideaki Mochizuki, Takehiko Morioka
1Division of Respiratory Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-Cho, Itabashi-Ku, Tokyo, 177-0015, Japan.
Abstract:
We report a case of bucillamine-induced interstitial pneumonia accompanied by severe hypoxemia in an 83-year-old woman who had rheumatoid arthritis. Respiratory failure worsened even after withdrawal of bucillamine and administration of high-dose corticosteroids, and mechanical ventilation was required. A review of 15 cases with bucillamine-induced pulmonary injury suggests that advanced age may be associated with the development of severe interstitial pneumonia. Bucillamine can cause corticosteroid-resistant and life-threatening lung injury, especially in the elderly.
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