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Biosensor-based on-site explosives detection using aptamers as recognition elements.

Eva Ehrentreich-Förster1, Dagmar Orgel, Andrea Krause-Griep

  • 1Fraunhofer Institute for Biomedical Technology, Am Mühlenberg 13, Potsdam, 14476, Germany. eva.ehrentreich@ibmt.fhg.de

Analytical and Bioanalytical Chemistry
|May 28, 2008
PubMed
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This study developed aptamer-based fiber-optic biosensors for detecting the explosive trinitrotoluene (TNT) in soil. These robust biosensors offer rapid, on-site analysis for effective decontamination strategies.

Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Soil contamination from military activities necessitates reliable detection methods for effective decontamination.
  • Biosensor devices offer flexible on-site analysis capabilities.
  • Fiber-optic evanescent field techniques combined with molecular recognition elements enable sensitive detection of explosives.

Purpose of the Study:

  • To develop specific aptamers for detecting the explosive molecule trinitrotoluene (TNT).
  • To utilize these aptamers as capture molecules in a fiber-optic biosensor.
  • To characterize aptamers using biosensor measurements.

Main Methods:

  • Development of synthetic high-affinity nucleic acid aptamers for TNT detection.
  • Integration of aptamers into a fiber-optic biosensor system.

Related Experiment Videos

  • Utilizing fiber-optic evanescent field techniques for sensitive detection.

    • Main Results:

    • Specific aptamers capable of detecting TNT were successfully developed.
    • The aptamer-based fiber-optic biosensor demonstrated robustness and sensitivity.
    • The biosensor effectively discriminated between different explosive molecules and was insensitive to other soil components.

    Conclusions:

    • Aptamer-based fiber-optic biosensors provide a sensitive, robust, and rapid method for TNT detection in soil.
    • These biosensors are suitable for both long-term contaminated sites and urgent spill response.
    • The technology has potential for incorporation into portable devices for on-site environmental monitoring.