Related Experiment Video
Updated: Jul 5, 2026
11:31
Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
Published on: July 4, 2018
[Mast cell-rich aluminium granuloma]
T Hansen1, L Klimek, F Bittinger
1Institut für Pathologie, Johannes-Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101, Mainz. hansen@pathologie.klinik.uni-mainz.de
Der Pathologe
|May 28, 2008
Summary
Subcutaneous nodules from aluminium hyposensitization can develop into granulomas. Increased mast cells in these aluminium granulomas may be linked to a higher incidence of urticaria post-immunotherapy.
Area of Science:
- Immunology
- Dermatopathology
Background:
- Hyposensitization therapy using aluminium hydroxide-absorbed solutions can lead to persistent subcutaneous nodules at injection sites.
- These nodules represent a form of aluminium granuloma.
Observation:
- A patient developed increasing urticaria two years after specific immunotherapy.
- Microscopic examination of the aluminium granuloma revealed inflammatory infiltrates and necrotic areas.
Findings:
- A novel histological finding of numerous mast cells surrounding necrotic areas within the aluminium granuloma was observed.
- This increased mast cell population is a previously unreported phenomenon in aluminium granuloma.
Implications:
- The presence of abundant mast cells in aluminium granuloma may indicate a potential association with urticaria.
- This association might be more common than previously recognized, suggesting further investigation into immunotherapy-induced reactions.
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