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Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: initial
Katja Oberholzer1, Andreas Pohlmann, Wolfgang Schreiber
1Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University Mainz, Mainz, Germany.
Purpose:
To investigate the feasibility and impact of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer.
Materials And Methods:
A total of 48 patients underwent DCE-MRI to assess tumor microcirculation based on a two-compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma.
Results:
Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k(21), P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate (P = 0.005), while amplitude A increased moderately after therapy (P = 0.136).
Conclusion:
DCE-MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring.
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