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Updated: Jul 5, 2026

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

Silver nanoparticles inhibit hepatitis B virus replication.

Lei Lu¹, Raymond Wai-Yin Sun, Rong Chen

¹Department of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

Antiviral Therapy

|May 29, 2008

Summary

Silver nanoparticles show potential against hepatitis B virus (HBV). These nanoparticles inhibit HBV RNA and extracellular virion production, suggesting a novel antiviral mechanism for HBV infection.

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Published on: May 10, 2022

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Last Updated: Jul 5, 2026

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Area of Science:

Nanotechnology
Virology
Biochemistry

Background:

Silver nanoparticles (AgNPs) demonstrate cytoprotective effects against HIV.
Their impact on other viruses, like hepatitis B virus (HBV), is largely unknown.

Purpose of the Study:

To investigate the antiviral effects of silver nanoparticles on hepatitis B virus (HBV) in vitro.

Main Methods:

Preparation of silver nanoparticles (Ag10Ns and Ag50Ns) with distinct sizes.
Assessment of anti-HBV activity using the HepAD38 cell line.
Analysis of viral DNA, RNA, and particle interactions using gel mobility shift and electronic microscopy assays.

Main Results:

Ag10Ns and Ag50Ns reduced extracellular HBV DNA formation by over 50%.
Silver nanoparticles inhibited intracellular HBV RNA production but had minimal impact on HBV cccDNA.
Direct interaction between Ag10Ns and HBV DNA/viral particles was observed.

Conclusions:

Silver nanoparticles effectively inhibit in vitro HBV RNA and extracellular virion production.
The antiviral mechanism is hypothesized to involve direct interaction with HBV DNA or viral particles.