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Updated: Jul 5, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Published on: May 16, 2021
Marine natural product libraries for high-throughput screening and rapid drug discovery
Tim S Bugni1, Burt Richards, Leen Bhoite
1Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, Utah 84112, USA.
Abstract:
There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
