Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytomas and oligodendrogliomas.

Neuro-oncology·2025
Same author

Influence of myelo-architectures on direct cortical response evoked by electrical stimulation.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025
Same author

Return to intensive sport activities following awake functional-guided surgical resection of IDH-mutated low-grade glioma.

Journal of neuro-oncology·2025
Same author

Efficacy of hybrid remote neuropsychological rehabilitation on cognitive complaints in post-therapeutic lower-grade glioma: the FREEDOME randomized study protocol.

Frontiers in psychology·2025
Same author

Integrating direct electrical stimulation with brain connectivity predicts lesion-induced language impairment and recovery.

Communications medicine·2025
Same author

Gold standard for estimation of propagation velocity from axono- or cortico-cortical evoked potentials? A case study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025

Related Experiment Video

Updated: Jul 5, 2026

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

Brain tumors and epilepsy.

Christian Brogna1, Santiago Gil Robles, Hugues Duffau

  • 1Department of Neuroscience - Neurosurgery, Sapienza University of Rome, Viale del Policlinico, 155, 00185 Rome, Italy. christian.brogna@tin.it

Expert Review of Neurotherapeutics
|May 29, 2008
PubMed
Summary
This summary is machine-generated.

Integrating epilepsy management with neuro-oncology is crucial for brain tumor patients. Surgical resection offers significant benefits for those with intractable seizures, improving quality of life.

More Related Videos

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Related Experiment Videos

Last Updated: Jul 5, 2026

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Area of Science:

  • Neuro-oncology
  • Epileptology
  • Neurosurgery

Background:

  • Brain tumors frequently cause seizures, necessitating integrated neuro-oncological and epileptological management.
  • Seizure frequency varies with tumor grade due to distinct epileptogenesis mechanisms.
  • Understanding pathological neural networks in low-grade gliomas is key to managing seizures, cognitive deficits, and plasticity.

Purpose of the Study:

  • To emphasize the importance of integrating epilepsy management principles into neuro-oncology.
  • To review the role of antiepileptic drugs considering tumor evolution and multidisciplinary treatment.
  • To assess the efficacy of surgical resection for intractable epilepsy in brain tumor patients.

Main Methods:

  • Review of current theories on pathological neural networks and connectionism.
  • Analysis of general epilepsy management principles applied to neuro-oncology.
  • Evaluation of outcomes following surgical resection for brain tumors with intractable epilepsy.

Main Results:

  • Over two-thirds of brain tumor patients with intractable epilepsy benefit from surgical resection.
  • Surgery improves both oncological outcomes and quality of life.
  • Approximately 15% of patients may still experience intractable seizures post-surgery, with potential insular involvement.

Conclusions:

  • A comprehensive understanding of tumor natural history is vital for selecting antiepileptic drugs.
  • Surgical resection is a viable option for many brain tumor patients with intractable epilepsy.
  • Further investigation into invasive EEG and repeat surgery may be necessary for refractory cases.