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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...

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Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
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Published on: August 22, 2016

Improving skin function with CM-glucan, a biological response modifier from yeast.

F Zulli1, F Suter, H Biltz

  • 1Mibelle AG Cosmetics, Bolimattstr. 1, 5024 Buchs, Switzerland.

International Journal of Cosmetic Science
|May 29, 2008
PubMed
Summary

Carboxymethyl glucan (CM-glucan), derived from baker's yeast, enhances skin's natural defenses against UV damage and irritants. This immune-stimulating compound promotes skin cell growth and accelerates healing for improved skin function.

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Area of Science:

  • Dermatology
  • Immunology
  • Biochemistry

Background:

  • Yeast preparations have historical cosmetic and pharmaceutical uses.
  • Baker's yeast glucan acts as a biological response modifier, activating natural defenses and wound healing.
  • UV irradiation can suppress skin immunity by depleting Langerhans' cells and keratinocytes.

Purpose of the Study:

  • To develop a water-soluble glucan derivative, carboxymethyl glucan (CM-glucan), for topical formulations.
  • To investigate the in vitro and in vivo functional properties of CM-glucan.
  • To assess CM-glucan's efficacy in protecting and improving stressed skin.

Main Methods:

  • Modification of pure yeast glucan into water-soluble CM-glucan.
  • In vitro cell culture experiments assessing CM-glucan's effects on UV-A irradiated skin cells.
  • Placebo-controlled in vivo studies on healthy volunteers evaluating CM-glucan's protective effects against UV-A and detergent challenges.

Main Results:

  • CM-glucan protected skin cells against UV-A-induced antioxidant depletion and promoted keratinocyte growth in vitro.
  • Pretreatment with CM-glucan provided significant protection against UV-A irradiation and detergent-induced skin damage in vivo.
  • CM-glucan was found to enhance the stratum corneum renewal rate.

Conclusions:

  • CM-glucan is an effective topical agent for protecting stressed skin.
  • This modified yeast glucan shows potential as a non-specific immune-stimulator for dermatological applications.
  • CM-glucan offers a novel approach to mitigate UV-induced immunosuppression and enhance skin barrier function.