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[Diffusion of minocycline in pulmonary tissue]
E Naline1, J P Roudière, P Cordonnier
1Laboratoire de Biochimie, Centre Hospitalier de Versailles, Le Chesnay.
Therapie
|January 1, 1991
Summary
Minocycline effectively penetrates lung tissue, with a mean tissue-to-plasma concentration ratio of 3.17. This antibiotic demonstrates good distribution in both cancerous and surrounding lung tissues.
Area of Science:
- Pharmacology
- Oncology
- Respiratory Medicine
Context:
- Lung cancer treatment
- Antibiotic efficacy
- Drug distribution studies
Purpose:
- To evaluate minocycline penetration into human lung tissue.
- To determine minocycline concentrations in tumor and peritumoral tissues.
- To assess the tissue-to-plasma concentration ratio of minocycline.
Summary:
- Minocycline was administered orally to 14 lung cancer patients (100 mg twice daily for 3 days, plus 100 mg on surgery day).
- Plasma and resected lung tissue samples were analyzed for minocycline concentrations.
- The mean lung tissue to plasma concentration ratio was 3.17, consistent in tumoral and peritumoral areas.
Impact:
- Demonstrates significant minocycline penetration into lung tissue.
- Provides evidence for potential therapeutic applications of minocycline in lung conditions.
- Supports further research into minocycline's role in treating lung diseases, including cancer.