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Cost-effectiveness analysis of routine rotavirus vaccination in Brazil

Patrícia Coelho de Soárez1, Joice Valentim, Ana Marli Christovam Sartori

  • 1Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brasil. pcsoarez@uol.com.br

Revista Panamericana De Salud Publica = Pan American Journal of Public Health
|May 29, 2008
PubMed

Insights

A universal rotavirus vaccination program in Brazil is a cost-effective strategy, preventing over 1.7 million cases and 700 deaths in children under five. This analysis considered healthcare and societal perspectives.

Area of Science:

  • Public Health
  • Health Economics
  • Vaccinology

Background:

  • Rotavirus gastroenteritis is a significant cause of morbidity and mortality in young children globally.
  • Brazil's large pediatric population presents a substantial burden of rotavirus disease.

Purpose of the Study:

  • To evaluate the cost-effectiveness of a universal rotavirus vaccination program in Brazil for children under five.
  • To analyze the economic impact from both healthcare system and societal perspectives.

Main Methods:

  • A decision-tree model simulated clinical and economic outcomes for a hypothetical cohort of 3.3 million newborns over five years.
  • Probabilities and costs were sourced from published research and national data.
  • Sensitivity analyses were performed to assess the impact of key parameter variations.

Main Results:

  • The program was projected to prevent 1,735,351 rotavirus cases and 703 deaths over five years.
  • At R$18.6 per dose, the program cost R$121.7 million, saving R$38.5 million in direct public healthcare costs and R$71.8 million in societal costs.
  • Cost per life-year saved was R$1,028 (societal) and R$1,713 (healthcare system).

Conclusions:

  • Universal rotavirus vaccination is a cost-effective intervention in Brazil from both societal and healthcare system viewpoints.
  • Key factors influencing cost-effectiveness include diarrhea incidence, severity, vaccine coverage, and price.
Abstract

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