Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Trihybrid Crosses02:27

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Dihybrid Crosses01:18

Dihybrid Crosses

Overview
Dihybrid Crosses01:18

Dihybrid Crosses

Overview
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Monohybrid Crosses01:20

Monohybrid Crosses

Overview
Monohybrid Crosses01:20

Monohybrid Crosses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Caenorhabditis becei</i> recombinant inbred lines (beRILs) reveal the scope of heritable variation within a gonochoristic nematode population.

bioRxiv : the preprint server for biology·2026
Same author

Global genomic diversity of the selfing nematode <i>Caenorhabditis tropicalis</i> correlates with geography.

bioRxiv : the preprint server for biology·2026
Same author

Caenorhabditis diversity on Pohnpei, Micronesia, provides evidence that the Elegans Supergroup has its roots in the Americas and diversified in the Pacific en route to Asia.

Evolution; international journal of organic evolution·2026
Same author

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

<i>Caenorhabditis briggsae</i> ancestral genomic hyper-diversity contrasts with globally distributed genome-wide haplotypes.

bioRxiv : the preprint server for biology·2025
Same author

Natural variation suggests candidate genes underlying <i>Caenorhabditis elegans</i> susceptibility to diverse toxicants.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jul 4, 2026

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi
06:44

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Published on: October 5, 2018

Breeding designs for recombinant inbred advanced intercross lines.

Matthew V Rockman1, Leonid Kruglyak

  • 1Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA. mrockman@princeton.edu

Genetics
|May 29, 2008
PubMed
Summary

Simple breeding designs for generating recombinant inbred lines are effective for genetic mapping. These methods efficiently expand genetic maps and improve fine-mapping resolution for complex traits.

More Related Videos

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

Related Experiment Videos

Last Updated: Jul 4, 2026

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi
06:44

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Published on: October 5, 2018

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

Area of Science:

  • Genetics
  • Quantitative Genetics
  • Genomic Mapping

Background:

  • Recombinant inbred lines (RILs) are crucial for mapping complex traits.
  • Advanced intercross lines (AILs) increase recombination breakpoint density for enhanced mapping.
  • Understanding breeding design impacts on RIL utility is essential.

Purpose of the Study:

  • To evaluate the influence of different intercross breeding designs on the effectiveness of RILs for genetic mapping.
  • To compare various mating schemes in terms of genetic map expansion, fine-mapping resolution, and control of genetic drift.

Main Methods:

  • Investigated multiple intercross breeding designs for generating RILs.
  • Assessed map expansion, fine-mapping resolution, and genetic drift control for each design.
  • Compared random pair mating, inbreeding avoidance schemes, circular mating, and random mating with offspring number variance.

Main Results:

  • The simplest design (random pair mating with two offspring per pair) matched extreme inbreeding avoidance schemes in map expansion and resolution.
  • Circular mating designs showed minimal advantage in drift control and reduced map expansion.
  • Random-mating designs with variable offspring numbers performed poorly in increasing mapping resolution.
  • Monogamy constraints had no impact on RIL population quality when parental contributions were equal.

Conclusions:

  • The most straightforward intercross breeding designs are highly suitable for generating effective RIL populations.
  • Simple, easily performed crosses can yield populations with high recombination density for complex trait mapping.
  • Optimized breeding designs can enhance the power of RILs in genetic studies.