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Updated: Jul 4, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

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Zebrafish as a cancer model.

Harma Feitsma1, Edwin Cuppen

  • 1Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

Molecular Cancer Research : MCR
|May 29, 2008
PubMed
Summary
This summary is machine-generated.

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Zebrafish are a valuable model organism for studying human cancer, developing diverse tumor types with similar gene pathways. Despite low incidence and late onset, their unique imaging and screening capabilities offer distinct advantages in cancer research.

Area of Science:

  • Biomedical Research
  • Cancer Biology
  • Model Organisms

Background:

  • Zebrafish have emerged as a significant model organism in biomedical research.
  • Initially studied for developmental biology, zebrafish are now increasingly used to model human diseases like cancer.

Purpose of the Study:

  • To provide a comprehensive overview of the current state of zebrafish as a model in cancer research.
  • To highlight the experimental advantages and characteristics of zebrafish in cancer studies.

Main Methods:

  • Review of approximately 50 articles published since 2000 utilizing zebrafish as a cancer model.
  • Analysis of various strategies employed, including carcinogenic treatments, cell transplantation, genetic screens, and transgenics.
  • Comparison of zebrafish tumor development with human and mouse models.

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Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Published on: June 19, 2021

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Last Updated: Jul 4, 2026

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Published on: March 31, 2015

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish
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Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish

Published on: April 25, 2017

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis
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Main Results:

  • Zebrafish can develop nearly all known human tumor types with similar morphology and gene expression pathways.
  • Tumor incidences in zebrafish are relatively low but consistent among mutants, with late-onset development.
  • Tumor spectra can differ between zebrafish, mice, and humans.

Conclusions:

  • The zebrafish model offers unique advantages for cancer research, including in vivo imaging of tumor progression and high-throughput screening for chemical and genetic modifiers.
  • Zebrafish complement existing cancer models, providing a valuable niche for specific experimental approaches.
  • Despite some differences in tumor spectra, zebrafish represent a powerful tool for advancing our understanding of cancer biology and developing new therapies.