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Naltrexone-induced hypothermia in the rat
European Journal of Pharmacology
|October 1, 1976
Summary
High doses of naltrexone can lower body temperature in rats by activating heat loss mechanisms, not by central opiate receptor displacement. This study investigated the hypothermic effect of naltrexone.
Area of Science:
- Pharmacology
- Neuroscience
- Thermoregulation
Background:
- Naltrexone, an opioid antagonist, has been observed to induce hypothermia in abstinent humans.
- The precise mechanism behind naltrexone-induced hypothermia remains unclear.
- Previous hypotheses suggested a link to delayed opioid withdrawal or endogenous substance displacement.